Content Status
Type
Linked Node
First Line LPA [FLLPA]
Learning ObjectivesProvide an overview of the first line LPA
Indications for use of FLLPA
Results it provides and its interpretations
H5Content
Content
First Line (FL) LPA
- Performed using GenoType MTBDR plus ver 2.0 kit
- GenoType MTBDR plus (Figure) identifies:
- Mutations in the Rif-resistance Determining Region (RRDR) of rpoB gene (from codon 505 to 533) to detect Rifampicin resistance
- Mutations in the inhA promoter (from -16 to -8 nucleotides upstream) and the katG (codon 315) regions to identify Isoniazid resistance.
Figure: GenoType MTBDR plus FL-LPA strip to determine Wild Type genes and mutations responsible for resistance to Rifampicin and Isoniazid; Source: GLI LPA Guidance Document.
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Align with all learning objectives
ManuMathew Wed, 16/02/2022 - 18:47
Please align content with all learning objectives.
Approved in B7
Namrata Tue, 22/02/2022 - 17:20
Approved in B7