Constituents of Patient-wise Boxes [PWB] of Longer Oral M/XDR-TB Regimen

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Constituents of Patient-wise Boxes [PWB] of Longer Oral M/XDR-TB Regimen

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PWB for longer oral M/XDR regimen.

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Standard monthly Drug-resistant TB (DR-TB) Patient-wise Boxes (PWBs) are utilized for patients initiated on a longer Multi/ Extensively Drug-resistant TB (M/XDR-TB) regimen. These PWBs are constituted either at the National TB Elimination Programme (NTEP) State Drug Store (SDS) level or District Drug Store Level (DDS). Child-friendly formulations of second-line anti-TB drugs are also available.

The constituents of the monthly standard patient-wise boxes (drugs, drug strength and weight-band wise medicinal formulations) are provided in the table below:

Table: Constituents of Monthly Standard PWB of Longer Oral Multi (M)/ Extensively Drug-resistant TB (XDR-TB) Regimen; *Source: Guidelines for PMDT, India 2021, p133.*
Standard PWB*		Continue till complete treatment
Drugs	Strength	16-29 kg	30-46 kg	48-70 kg	>70 kg
Tab. Levofloxacin	250/ 500 mg	250 mg *30 tab	500 mg 30 tab + 250 mg 30 tab	500 mg *60 tab	500 mg *60 tab
Tab. Linezolid^#	600 mg	600 mg *30 tab^#	600 mg *30 tab	600 mg *30 tab	600 mg *30 tab
Tab. Clofazimine	50/ 100 mg	50 mg *30 tab	100 mg *30 tab	100 mg *30 tab	100 mg *60 tab
Tab. Cycloserine	250 mg	250 mg *30 tab	250 mg *60 tab	250 mg *90 tab	250 mg *120 tab
Tab. Pyridoxine	50/ 100 mg	50 mg *30 tab	100 mg *30 tab	100 mg *30 tab	100 mg *30 tab
Bedaquiline bottle	100 mg	1 Jar (Jar of 188 tablets for full course)
*No separate box for Intensive Phase (IP) and Continuation Phase (CP). ^#Tab. linezolid is available in 600 mg only. When prescribed with a modified dose of 300 mg OD, the patient should be advised to divide the pill in half, consume half of the pill and throw the remaining half of the pill in the drain. Longer oral M/XDR-TB regimen duration: 18-20 months