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Critical Concentration and Reconstitution of PZA
Learning ObjectivesHighlight critical drug concentrations and drug reconstitution
Critical Concentration for PZA Drugs Recommended for the Treatment of DS- TB
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Anti TB drugs |
CC (ug/ml) for DST medium |
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Pyrazinamide |
100μg/mL
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Reconstitution of PZA Lyophilized Drugs (Drug stock preparation)
Reconstitute the PZA drug vial with 2.5 ml sterile distilled/ deionized water to make a stock solution of 8000 μg/ml. Failure to use the appropriate volume will invalidate these tests.
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Drug lyophilised
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Concentration of reconstituted agent μg/mL*
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Volume added to each MGIT tube
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Final concentration in MGIT tubes
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Pyrazinamide (PZA) |
8000 μg/ml |
100 μl |
100μg/mL
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*PZA must be reconstituted using 2.5 mL sterile/deionized water to achieve the concentration indicated.
Resource
Mycobacteriology Laboratory Manual
Assessment
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Question |
Answer 1 |
Answer 2 |
Answer 3 |
Answer 4 |
Correct answer |
Correct explanation |
Page id |
Part of Pre-test |
Part of Post-te |
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Which of the following is the Critical Concentration for PZA drugs recommended for the treatment of DS- TB?
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100μg/mL | 10μg/mL | 1000μg/mL | 800μg/mL | Answer 1 | Critical Concentration for PZA drugs recommended for the treatment of DS- TB is:100μg/mL. |
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